ParkinsonCanadaV1, Main, Exploration, bibRecord, 000C62

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

Identifieur interne : 000C62 ( Main/Exploration ); précédent : 000C61; suivant : 000C63

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

Auteurs : Sruti Rayaprolu [États-Unis] ; Bianca Mullen [États-Unis] ; Matt Baker [États-Unis] ; Timothy Lynch [Irlande (pays)] ; Elizabeth Finger [Canada] ; William W. Seeley [États-Unis] ; Kimmo J. Hatanpaa [États-Unis] ; Catherine Lomen-Hoerth [États-Unis] ; Andrew Kertesz [Canada] ; Eileen H. Bigio [États-Unis] ; Carol Lippa [États-Unis] ; Keith A. Josephs [États-Unis] ; David S. Knopman [États-Unis] ; Charles L. White [États-Unis] ; Richard Caselli [États-Unis] ; Ian R. Mackenzie [Canada] ; Bruce L. Miller [États-Unis] ; Magdalena Boczarska-Jedynak [Pologne] ; Grzegorz Opala [Pologne] ; Anna Krygowska-Wajs [Pologne] ; Maria Barcikowska [Pologne] ; Steven G. Younkin [États-Unis] ; Ronald C. Petersen [États-Unis] ; Nilüfer Ertekin-Taner [États-Unis] ; Ryan J. Uitti [États-Unis] ; James F. Meschia [États-Unis] ; Kevin B. Boylan [États-Unis] ; Bradley F. Boeve [États-Unis] ; Neill R. Graff-Radford [États-Unis] ; Zbigniew K. Wszolek [États-Unis] ; Dennis W. Dickson [États-Unis] ; Rosa Rademakers [États-Unis] ; Owen A. Ross [États-Unis]

Source :

Molecular Neurodegeneration [ 1750-1326 ] ; 2013.

RBID : PMC:3691612

English descriptors

KwdEn :
- Aged, Female, Frontotemporal Dementia (genetics), Gene Frequency, Genetic Predisposition to Disease (genetics), Genotype, Humans, Male, Membrane Glycoproteins (genetics), Middle Aged, Neurodegenerative Diseases (genetics), Parkinson Disease (genetics), Polymorphism, Single Nucleotide, Real-Time Polymerase Chain Reaction, Receptors, Immunologic (genetics).
MESH :
- chemical , genetics : Membrane Glycoproteins, Receptors, Immunologic.
- genetics : Frontotemporal Dementia, Genetic Predisposition to Disease, Neurodegenerative Diseases, Parkinson Disease.
- Aged, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Real-Time Polymerase Chain Reaction.

Abstract

Background

A rare variant in the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) gene has been reported to be a genetic risk factor for Alzheimer’s disease by two independent groups (Odds ratio between 2.9-4.5). Given the key role of TREM2 in the effective phagocytosis of apoptotic neuronal cells by microglia, we hypothesized that dysfunction of TREM2 may play a more generalized role in neurodegeneration. With this in mind we set out to assess the genetic association of the Alzheimer’s disease-related risk variant in TREM2 (rs75932628, p.R47H) with other related neurodegenerative disorders.

Results

The study included 609 patients with frontotemporal dementia, 765 with amyotrophic lateral sclerosis, 1493 with Parkinson’s disease, 772 with progressive supranuclear palsy, 448 with ischemic stroke and 1957 controls subjects free of neurodegenerative disease. A significant association was observed for the TREM2 p.R47H substitution in susceptibility to frontotemporal dementia (OR = 5.06; p-value = 0.001) and Parkinson’s disease (OR = 2.67; p-value = 0.026), while no evidence of association with risk of amyotrophic lateral sclerosis, progressive supranuclear palsy or ischemic stroke was observed.

Conclusions

Our results suggest that the TREM2 p.R47H substitution is a risk factor for frontotemporal dementia and Parkinson’s disease in addition to Alzheimer’s disease. These findings suggest a more general role for TREM2 dysfunction in neurodegeneration, which could be related to its role in the immune response.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691612

DOI: 10.1186/1750-1326-8-19
PubMed: 23800361
PubMed Central: 3691612

Affiliations:

Canada, Irlande (pays), Pologne, États-Unis

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease</title>
<author><name sortKey="Rayaprolu, Sruti" sort="Rayaprolu, Sruti" uniqKey="Rayaprolu S" first="Sruti" last="Rayaprolu">Sruti Rayaprolu</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mullen, Bianca" sort="Mullen, Bianca" uniqKey="Mullen B" first="Bianca" last="Mullen">Bianca Mullen</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baker, Matt" sort="Baker, Matt" uniqKey="Baker M" first="Matt" last="Baker">Matt Baker</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Dublin Neurological Institute at the Mater Misericordiae University Hospital, Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital, Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Finger, Elizabeth" sort="Finger, Elizabeth" uniqKey="Finger E" first="Elizabeth" last="Finger">Elizabeth Finger</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seeley, William W" sort="Seeley, William W" uniqKey="Seeley W" first="William W" last="Seeley">William W. Seeley</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Neurology, University of California, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hatanpaa, Kimmo J" sort="Hatanpaa, Kimmo J" uniqKey="Hatanpaa K" first="Kimmo J" last="Hatanpaa">Kimmo J. Hatanpaa</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Department of Pathology and Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lomen Hoerth, Catherine" sort="Lomen Hoerth, Catherine" uniqKey="Lomen Hoerth C" first="Catherine" last="Lomen-Hoerth">Catherine Lomen-Hoerth</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Neurology, University of California, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kertesz, Andrew" sort="Kertesz, Andrew" uniqKey="Kertesz A" first="Andrew" last="Kertesz">Andrew Kertesz</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bigio, Eileen H" sort="Bigio, Eileen H" uniqKey="Bigio E" first="Eileen H" last="Bigio">Eileen H. Bigio</name>
<affiliation wicri:level="1"><nlm:aff id="I6">Cognitive Neurology & Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cognitive Neurology & Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL</wicri:regionArea>
<wicri:noRegion>IL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lippa, Carol" sort="Lippa, Carol" uniqKey="Lippa C" first="Carol" last="Lippa">Carol Lippa</name>
<affiliation wicri:level="1"><nlm:aff id="I7">Department of Neurology, Drexel University College of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Drexel University College of Medicine, Philadelphia, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name>
<affiliation wicri:level="1"><nlm:aff id="I8">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<wicri:noRegion>MN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S" last="Knopman">David S. Knopman</name>
<affiliation wicri:level="1"><nlm:aff id="I8">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<wicri:noRegion>MN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="White, Charles L" sort="White, Charles L" uniqKey="White C" first="Charles L" last="White">Charles L. White</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Department of Pathology and Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Caselli, Richard" sort="Caselli, Richard" uniqKey="Caselli R" first="Richard" last="Caselli">Richard Caselli</name>
<affiliation wicri:level="1"><nlm:aff id="I9">Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Scottsdale, AZ</wicri:regionArea>
<wicri:noRegion>AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mackenzie, Ian R" sort="Mackenzie, Ian R" uniqKey="Mackenzie I" first="Ian R" last="Mackenzie">Ian R. Mackenzie</name>
<affiliation wicri:level="1"><nlm:aff id="I10">Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L" last="Miller">Bruce L. Miller</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Neurology, University of California, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boczarska Jedynak, Magdalena" sort="Boczarska Jedynak, Magdalena" uniqKey="Boczarska Jedynak M" first="Magdalena" last="Boczarska-Jedynak">Magdalena Boczarska-Jedynak</name>
<affiliation wicri:level="1"><nlm:aff id="I11">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name>
<affiliation wicri:level="1"><nlm:aff id="I11">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krygowska Wajs, Anna" sort="Krygowska Wajs, Anna" uniqKey="Krygowska Wajs A" first="Anna" last="Krygowska-Wajs">Anna Krygowska-Wajs</name>
<affiliation wicri:level="1"><nlm:aff id="I12">Department of Neurology, Jagiellonian University, Krakow, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Jagiellonian University, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barcikowska, Maria" sort="Barcikowska, Maria" uniqKey="Barcikowska M" first="Maria" last="Barcikowska">Maria Barcikowska</name>
<affiliation wicri:level="1"><nlm:aff id="I13">Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw</wicri:regionArea>
<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G" last="Younkin">Steven G. Younkin</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C" last="Petersen">Ronald C. Petersen</name>
<affiliation wicri:level="1"><nlm:aff id="I8">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<wicri:noRegion>MN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ertekin Taner, Nilufer" sort="Ertekin Taner, Nilufer" uniqKey="Ertekin Taner N" first="Nilüfer" last="Ertekin-Taner">Nilüfer Ertekin-Taner</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J" last="Uitti">Ryan J. Uitti</name>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meschia, James F" sort="Meschia, James F" uniqKey="Meschia J" first="James F" last="Meschia">James F. Meschia</name>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boylan, Kevin B" sort="Boylan, Kevin B" uniqKey="Boylan K" first="Kevin B" last="Boylan">Kevin B. Boylan</name>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley F" last="Boeve">Bradley F. Boeve</name>
<affiliation wicri:level="1"><nlm:aff id="I8">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<wicri:noRegion>MN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R" last="Graff-Radford">Neill R. Graff-Radford</name>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K" last="Wszolek">Zbigniew K. Wszolek</name>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rademakers, Rosa" sort="Rademakers, Rosa" uniqKey="Rademakers R" first="Rosa" last="Rademakers">Rosa Rademakers</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A" last="Ross">Owen A. Ross</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23800361</idno>
<idno type="pmc">3691612</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691612</idno>
<idno type="RBID">PMC:3691612</idno>
<idno type="doi">10.1186/1750-1326-8-19</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000506</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000506</idno>
<idno type="wicri:Area/Pmc/Curation">000506</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000506</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000574</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000574</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000902</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000902</idno>
<idno type="wicri:Area/PubMed/Curation">000902</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000902</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000902</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000902</idno>
<idno type="wicri:Area/Ncbi/Merge">001486</idno>
<idno type="wicri:Area/Ncbi/Curation">001486</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001486</idno>
<idno type="wicri:Area/Main/Merge">000C67</idno>
<idno type="wicri:Area/Main/Curation">000C62</idno>
<idno type="wicri:Area/Main/Exploration">000C62</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease</title>
<author><name sortKey="Rayaprolu, Sruti" sort="Rayaprolu, Sruti" uniqKey="Rayaprolu S" first="Sruti" last="Rayaprolu">Sruti Rayaprolu</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mullen, Bianca" sort="Mullen, Bianca" uniqKey="Mullen B" first="Bianca" last="Mullen">Bianca Mullen</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baker, Matt" sort="Baker, Matt" uniqKey="Baker M" first="Matt" last="Baker">Matt Baker</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Dublin Neurological Institute at the Mater Misericordiae University Hospital, Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital, Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Finger, Elizabeth" sort="Finger, Elizabeth" uniqKey="Finger E" first="Elizabeth" last="Finger">Elizabeth Finger</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seeley, William W" sort="Seeley, William W" uniqKey="Seeley W" first="William W" last="Seeley">William W. Seeley</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Neurology, University of California, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hatanpaa, Kimmo J" sort="Hatanpaa, Kimmo J" uniqKey="Hatanpaa K" first="Kimmo J" last="Hatanpaa">Kimmo J. Hatanpaa</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Department of Pathology and Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lomen Hoerth, Catherine" sort="Lomen Hoerth, Catherine" uniqKey="Lomen Hoerth C" first="Catherine" last="Lomen-Hoerth">Catherine Lomen-Hoerth</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Neurology, University of California, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kertesz, Andrew" sort="Kertesz, Andrew" uniqKey="Kertesz A" first="Andrew" last="Kertesz">Andrew Kertesz</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bigio, Eileen H" sort="Bigio, Eileen H" uniqKey="Bigio E" first="Eileen H" last="Bigio">Eileen H. Bigio</name>
<affiliation wicri:level="1"><nlm:aff id="I6">Cognitive Neurology & Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cognitive Neurology & Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL</wicri:regionArea>
<wicri:noRegion>IL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lippa, Carol" sort="Lippa, Carol" uniqKey="Lippa C" first="Carol" last="Lippa">Carol Lippa</name>
<affiliation wicri:level="1"><nlm:aff id="I7">Department of Neurology, Drexel University College of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Drexel University College of Medicine, Philadelphia, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name>
<affiliation wicri:level="1"><nlm:aff id="I8">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<wicri:noRegion>MN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S" last="Knopman">David S. Knopman</name>
<affiliation wicri:level="1"><nlm:aff id="I8">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<wicri:noRegion>MN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="White, Charles L" sort="White, Charles L" uniqKey="White C" first="Charles L" last="White">Charles L. White</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Department of Pathology and Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Caselli, Richard" sort="Caselli, Richard" uniqKey="Caselli R" first="Richard" last="Caselli">Richard Caselli</name>
<affiliation wicri:level="1"><nlm:aff id="I9">Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Scottsdale, AZ</wicri:regionArea>
<wicri:noRegion>AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mackenzie, Ian R" sort="Mackenzie, Ian R" uniqKey="Mackenzie I" first="Ian R" last="Mackenzie">Ian R. Mackenzie</name>
<affiliation wicri:level="1"><nlm:aff id="I10">Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L" last="Miller">Bruce L. Miller</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Neurology, University of California, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boczarska Jedynak, Magdalena" sort="Boczarska Jedynak, Magdalena" uniqKey="Boczarska Jedynak M" first="Magdalena" last="Boczarska-Jedynak">Magdalena Boczarska-Jedynak</name>
<affiliation wicri:level="1"><nlm:aff id="I11">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name>
<affiliation wicri:level="1"><nlm:aff id="I11">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krygowska Wajs, Anna" sort="Krygowska Wajs, Anna" uniqKey="Krygowska Wajs A" first="Anna" last="Krygowska-Wajs">Anna Krygowska-Wajs</name>
<affiliation wicri:level="1"><nlm:aff id="I12">Department of Neurology, Jagiellonian University, Krakow, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Jagiellonian University, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barcikowska, Maria" sort="Barcikowska, Maria" uniqKey="Barcikowska M" first="Maria" last="Barcikowska">Maria Barcikowska</name>
<affiliation wicri:level="1"><nlm:aff id="I13">Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw</wicri:regionArea>
<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G" last="Younkin">Steven G. Younkin</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C" last="Petersen">Ronald C. Petersen</name>
<affiliation wicri:level="1"><nlm:aff id="I8">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<wicri:noRegion>MN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ertekin Taner, Nilufer" sort="Ertekin Taner, Nilufer" uniqKey="Ertekin Taner N" first="Nilüfer" last="Ertekin-Taner">Nilüfer Ertekin-Taner</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J" last="Uitti">Ryan J. Uitti</name>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meschia, James F" sort="Meschia, James F" uniqKey="Meschia J" first="James F" last="Meschia">James F. Meschia</name>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boylan, Kevin B" sort="Boylan, Kevin B" uniqKey="Boylan K" first="Kevin B" last="Boylan">Kevin B. Boylan</name>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley F" last="Boeve">Bradley F. Boeve</name>
<affiliation wicri:level="1"><nlm:aff id="I8">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<wicri:noRegion>MN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R" last="Graff-Radford">Neill R. Graff-Radford</name>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K" last="Wszolek">Zbigniew K. Wszolek</name>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rademakers, Rosa" sort="Rademakers, Rosa" uniqKey="Rademakers R" first="Rosa" last="Rademakers">Rosa Rademakers</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A" last="Ross">Owen A. Ross</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Molecular Neurodegeneration</title>
<idno type="eISSN">1750-1326</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Frontotemporal Dementia (genetics)</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Middle Aged</term>
<term>Neurodegenerative Diseases (genetics)</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Receptors, Immunologic (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Receptors, Immunologic</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Frontotemporal Dementia</term>
<term>Genetic Predisposition to Disease</term>
<term>Neurodegenerative Diseases</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Real-Time Polymerase Chain Reaction</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>A rare variant in the Triggering Receptor Expressed on Myeloid cells 2 (<italic>TREM2</italic>
) gene has been reported to be a genetic risk factor for Alzheimer’s disease by two independent groups (Odds ratio between 2.9-4.5). Given the key role of TREM2 in the effective phagocytosis of apoptotic neuronal cells by microglia, we hypothesized that dysfunction of TREM2 may play a more generalized role in neurodegeneration. With this in mind we set out to assess the genetic association of the Alzheimer’s disease-related risk variant in <italic>TREM2</italic>
 (rs75932628, p.R47H) with other related neurodegenerative disorders.</p>
</sec>
<sec><title>Results</title>
<p>The study included 609 patients with frontotemporal dementia, 765 with amyotrophic lateral sclerosis, 1493 with Parkinson’s disease, 772 with progressive supranuclear palsy, 448 with ischemic stroke and 1957 controls subjects free of neurodegenerative disease. A significant association was observed for the TREM2 p.R47H substitution in susceptibility to frontotemporal dementia (OR = 5.06; p-value = 0.001) and Parkinson’s disease (OR = 2.67; p-value = 0.026), while no evidence of association with risk of amyotrophic lateral sclerosis, progressive supranuclear palsy or ischemic stroke was observed.</p>
</sec>
<sec><title>Conclusions</title>
<p>Our results suggest that the TREM2 p.R47H substitution is a risk factor for frontotemporal dementia and Parkinson’s disease in addition to Alzheimer’s disease. These findings suggest a more general role for TREM2 dysfunction in neurodegeneration, which could be related to its role in the immune response.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Colonna, M" uniqKey="Colonna M">M Colonna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hsieh, Cl" uniqKey="Hsieh C">CL Hsieh</name>
</author>
<author><name sortKey="Koike, M" uniqKey="Koike M">M Koike</name>
</author>
<author><name sortKey="Spusta, Sc" uniqKey="Spusta S">SC Spusta</name>
</author>
<author><name sortKey="Niemi, Ec" uniqKey="Niemi E">EC Niemi</name>
</author>
<author><name sortKey="Yenari, M" uniqKey="Yenari M">M Yenari</name>
</author>
<author><name sortKey="Nakamura, Mc" uniqKey="Nakamura M">MC Nakamura</name>
</author>
<author><name sortKey="Seaman, We" uniqKey="Seaman W">WE Seaman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paloneva, J" uniqKey="Paloneva J">J Paloneva</name>
</author>
<author><name sortKey="Manninen, T" uniqKey="Manninen T">T Manninen</name>
</author>
<author><name sortKey="Christman, G" uniqKey="Christman G">G Christman</name>
</author>
<author><name sortKey="Hovanes, K" uniqKey="Hovanes K">K Hovanes</name>
</author>
<author><name sortKey="Mandelin, J" uniqKey="Mandelin J">J Mandelin</name>
</author>
<author><name sortKey="Adolfsson, R" uniqKey="Adolfsson R">R Adolfsson</name>
</author>
<author><name sortKey="Bianchin, M" uniqKey="Bianchin M">M Bianchin</name>
</author>
<author><name sortKey="Bird, T" uniqKey="Bird T">T Bird</name>
</author>
<author><name sortKey="Miranda, R" uniqKey="Miranda R">R Miranda</name>
</author>
<author><name sortKey="Salmaggi, A" uniqKey="Salmaggi A">A Salmaggi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thrash, Jc" uniqKey="Thrash J">JC Thrash</name>
</author>
<author><name sortKey="Torbett, Be" uniqKey="Torbett B">BE Torbett</name>
</author>
<author><name sortKey="Carson, Mj" uniqKey="Carson M">MJ Carson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guerreiro, Rj" uniqKey="Guerreiro R">RJ Guerreiro</name>
</author>
<author><name sortKey="Lohmann, E" uniqKey="Lohmann E">E Lohmann</name>
</author>
<author><name sortKey="Bras, Jm" uniqKey="Bras J">JM Brás</name>
</author>
<author><name sortKey="Gibbs, Jr" uniqKey="Gibbs J">JR Gibbs</name>
</author>
<author><name sortKey="Rohrer, Jd" uniqKey="Rohrer J">JD Rohrer</name>
</author>
<author><name sortKey="Gurunlian, N" uniqKey="Gurunlian N">N Gurunlian</name>
</author>
<author><name sortKey="Dursun, B" uniqKey="Dursun B">B Dursun</name>
</author>
<author><name sortKey="Bilgic, B" uniqKey="Bilgic B">B Bilgic</name>
</author>
<author><name sortKey="Hanagasi, H" uniqKey="Hanagasi H">H Hanagasi</name>
</author>
<author><name sortKey="Gurvit, H" uniqKey="Gurvit H">H Gurvit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chouery, E" uniqKey="Chouery E">E Chouery</name>
</author>
<author><name sortKey="Delague, V" uniqKey="Delague V">V Delague</name>
</author>
<author><name sortKey="Bergougnoux, A" uniqKey="Bergougnoux A">A Bergougnoux</name>
</author>
<author><name sortKey="Koussa, S" uniqKey="Koussa S">S Koussa</name>
</author>
<author><name sortKey="Serre, J L" uniqKey="Serre J">J-L Serre</name>
</author>
<author><name sortKey="Megarbane, A" uniqKey="Megarbane A">A Mégarbané</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giraldo, M" uniqKey="Giraldo M">M Giraldo</name>
</author>
<author><name sortKey="Lopera, F" uniqKey="Lopera F">F Lopera</name>
</author>
<author><name sortKey="Siniard, Al" uniqKey="Siniard A">AL Siniard</name>
</author>
<author><name sortKey="Corneveaux, Jj" uniqKey="Corneveaux J">JJ Corneveaux</name>
</author>
<author><name sortKey="Schrauwen, I" uniqKey="Schrauwen I">I Schrauwen</name>
</author>
<author><name sortKey="Carvajal, J" uniqKey="Carvajal J">J Carvajal</name>
</author>
<author><name sortKey="Munoz, C" uniqKey="Munoz C">C Munoz</name>
</author>
<author><name sortKey="Ramirez Restrepo, M" uniqKey="Ramirez Restrepo M">M Ramirez-Restrepo</name>
</author>
<author><name sortKey="Gaiteri, C" uniqKey="Gaiteri C">C Gaiteri</name>
</author>
<author><name sortKey="Myers, Aj" uniqKey="Myers A">AJ Myers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jonsson, T" uniqKey="Jonsson T">T Jonsson</name>
</author>
<author><name sortKey="Stefansson, H" uniqKey="Stefansson H">H Stefansson</name>
</author>
<author><name sortKey="Steinberg, S" uniqKey="Steinberg S">S Steinberg</name>
</author>
<author><name sortKey="Jonsdottir, I" uniqKey="Jonsdottir I">I Jonsdottir</name>
</author>
<author><name sortKey="Jonsson, Pv" uniqKey="Jonsson P">PV Jonsson</name>
</author>
<author><name sortKey="Snaedal, J" uniqKey="Snaedal J">J Snaedal</name>
</author>
<author><name sortKey="Bjornsson, S" uniqKey="Bjornsson S">S Bjornsson</name>
</author>
<author><name sortKey="Huttenlocher, J" uniqKey="Huttenlocher J">J Huttenlocher</name>
</author>
<author><name sortKey="Levey, Ai" uniqKey="Levey A">AI Levey</name>
</author>
<author><name sortKey="Lah, Jj" uniqKey="Lah J">JJ Lah</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name>
</author>
<author><name sortKey="Gaiteri, C" uniqKey="Gaiteri C">C Gaiteri</name>
</author>
<author><name sortKey="Bodea, Lg" uniqKey="Bodea L">LG Bodea</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Mcelwee, J" uniqKey="Mcelwee J">J McElwee</name>
</author>
<author><name sortKey="Podtelezhnikov, Aa" uniqKey="Podtelezhnikov A">AA Podtelezhnikov</name>
</author>
<author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name>
</author>
<author><name sortKey="Xie, T" uniqKey="Xie T">T Xie</name>
</author>
<author><name sortKey="Tran, L" uniqKey="Tran L">L Tran</name>
</author>
<author><name sortKey="Dobrin, R" uniqKey="Dobrin R">R Dobrin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Otero, K" uniqKey="Otero K">K Otero</name>
</author>
<author><name sortKey="Turnbull, Ir" uniqKey="Turnbull I">IR Turnbull</name>
</author>
<author><name sortKey="Poliani, Pl" uniqKey="Poliani P">PL Poliani</name>
</author>
<author><name sortKey="Vermi, W" uniqKey="Vermi W">W Vermi</name>
</author>
<author><name sortKey="Cerutti, E" uniqKey="Cerutti E">E Cerutti</name>
</author>
<author><name sortKey="Aoshi, T" uniqKey="Aoshi T">T Aoshi</name>
</author>
<author><name sortKey="Tassi, I" uniqKey="Tassi I">I Tassi</name>
</author>
<author><name sortKey="Takai, T" uniqKey="Takai T">T Takai</name>
</author>
<author><name sortKey="Stanley, Sl" uniqKey="Stanley S">SL Stanley</name>
</author>
<author><name sortKey="Miller, M" uniqKey="Miller M">M Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paloneva, J" uniqKey="Paloneva J">J Paloneva</name>
</author>
<author><name sortKey="Kestila, M" uniqKey="Kestila M">M Kestila</name>
</author>
<author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
<author><name sortKey="Salminen, A" uniqKey="Salminen A">A Salminen</name>
</author>
<author><name sortKey="Bohling, T" uniqKey="Bohling T">T Bohling</name>
</author>
<author><name sortKey="Ruotsalainen, V" uniqKey="Ruotsalainen V">V Ruotsalainen</name>
</author>
<author><name sortKey="Hakola, P" uniqKey="Hakola P">P Hakola</name>
</author>
<author><name sortKey="Bakker, Ab" uniqKey="Bakker A">AB Bakker</name>
</author>
<author><name sortKey="Phillips, Jh" uniqKey="Phillips J">JH Phillips</name>
</author>
<author><name sortKey="Pekkarinen, P" uniqKey="Pekkarinen P">P Pekkarinen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rademakers, R" uniqKey="Rademakers R">R Rademakers</name>
</author>
<author><name sortKey="Baker, M" uniqKey="Baker M">M Baker</name>
</author>
<author><name sortKey="Nicholson, Am" uniqKey="Nicholson A">AM Nicholson</name>
</author>
<author><name sortKey="Rutherford, Nj" uniqKey="Rutherford N">NJ Rutherford</name>
</author>
<author><name sortKey="Finch, N" uniqKey="Finch N">N Finch</name>
</author>
<author><name sortKey="Soto Ortolaza, A" uniqKey="Soto Ortolaza A">A Soto-Ortolaza</name>
</author>
<author><name sortKey="Lash, J" uniqKey="Lash J">J Lash</name>
</author>
<author><name sortKey="Wider, C" uniqKey="Wider C">C Wider</name>
</author>
<author><name sortKey="Wojtas, A" uniqKey="Wojtas A">A Wojtas</name>
</author>
<author><name sortKey="Dejesus Hernandez, M" uniqKey="Dejesus Hernandez M">M DeJesus-Hernandez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forman, Ms" uniqKey="Forman M">MS Forman</name>
</author>
<author><name sortKey="Farmer, J" uniqKey="Farmer J">J Farmer</name>
</author>
<author><name sortKey="Johnson, Jk" uniqKey="Johnson J">JK Johnson</name>
</author>
<author><name sortKey="Clark, Cm" uniqKey="Clark C">CM Clark</name>
</author>
<author><name sortKey="Arnold, Se" uniqKey="Arnold S">SE Arnold</name>
</author>
<author><name sortKey="Coslett, Hb" uniqKey="Coslett H">HB Coslett</name>
</author>
<author><name sortKey="Chatterjee, A" uniqKey="Chatterjee A">A Chatterjee</name>
</author>
<author><name sortKey="Hurtig, Hi" uniqKey="Hurtig H">HI Hurtig</name>
</author>
<author><name sortKey="Karlawish, Jh" uniqKey="Karlawish J">JH Karlawish</name>
</author>
<author><name sortKey="Rosen, Hj" uniqKey="Rosen H">HJ Rosen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Knopman, Ds" uniqKey="Knopman D">DS Knopman</name>
</author>
<author><name sortKey="Boeve, Bf" uniqKey="Boeve B">BF Boeve</name>
</author>
<author><name sortKey="Parisi, Je" uniqKey="Parisi J">JE Parisi</name>
</author>
<author><name sortKey="Dickson, Dw" uniqKey="Dickson D">DW Dickson</name>
</author>
<author><name sortKey="Smith, Ge" uniqKey="Smith G">GE Smith</name>
</author>
<author><name sortKey="Ivnik, Rj" uniqKey="Ivnik R">RJ Ivnik</name>
</author>
<author><name sortKey="Josephs, Ka" uniqKey="Josephs K">KA Josephs</name>
</author>
<author><name sortKey="Petersen, Rc" uniqKey="Petersen R">RC Petersen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Neary, D" uniqKey="Neary D">D Neary</name>
</author>
<author><name sortKey="Snowden, Js" uniqKey="Snowden J">JS Snowden</name>
</author>
<author><name sortKey="Gustafson, L" uniqKey="Gustafson L">L Gustafson</name>
</author>
<author><name sortKey="Passant, U" uniqKey="Passant U">U Passant</name>
</author>
<author><name sortKey="Stuss, D" uniqKey="Stuss D">D Stuss</name>
</author>
<author><name sortKey="Black, S" uniqKey="Black S">S Black</name>
</author>
<author><name sortKey="Freedman, M" uniqKey="Freedman M">M Freedman</name>
</author>
<author><name sortKey="Kertesz, A" uniqKey="Kertesz A">A Kertesz</name>
</author>
<author><name sortKey="Robert, Ph" uniqKey="Robert P">PH Robert</name>
</author>
<author><name sortKey="Albert, M" uniqKey="Albert M">M Albert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gelb, Dj" uniqKey="Gelb D">DJ Gelb</name>
</author>
<author><name sortKey="Oliver, E" uniqKey="Oliver E">E Oliver</name>
</author>
<author><name sortKey="Gilman, S" uniqKey="Gilman S">S Gilman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meschia, Jf" uniqKey="Meschia J">JF Meschia</name>
</author>
<author><name sortKey="Brott, Tg" uniqKey="Brott T">TG Brott</name>
</author>
<author><name sortKey="Brown, Rd" uniqKey="Brown R">RD Brown</name>
</author>
<author><name sortKey="Crook, Rj" uniqKey="Crook R">RJ Crook</name>
</author>
<author><name sortKey="Frankel, M" uniqKey="Frankel M">M Frankel</name>
</author>
<author><name sortKey="Hardy, J" uniqKey="Hardy J">J Hardy</name>
</author>
<author><name sortKey="Merino, Jg" uniqKey="Merino J">JG Merino</name>
</author>
<author><name sortKey="Rich, Ss" uniqKey="Rich S">SS Rich</name>
</author>
<author><name sortKey="Silliman, S" uniqKey="Silliman S">S Silliman</name>
</author>
<author><name sortKey="Worrall, Bb" uniqKey="Worrall B">BB Worrall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Labbe, C" uniqKey="Labbe C">C Labbe</name>
</author>
<author><name sortKey="Soto Ortolaza, Ai" uniqKey="Soto Ortolaza A">AI Soto-Ortolaza</name>
</author>
<author><name sortKey="Rayaprolu, S" uniqKey="Rayaprolu S">S Rayaprolu</name>
</author>
<author><name sortKey="Harriott, Am" uniqKey="Harriott A">AM Harriott</name>
</author>
<author><name sortKey="Strongosky, Aj" uniqKey="Strongosky A">AJ Strongosky</name>
</author>
<author><name sortKey="Uitti, Rj" uniqKey="Uitti R">RJ Uitti</name>
</author>
<author><name sortKey="Van Gerpen, Ja" uniqKey="Van Gerpen J">JA Van Gerpen</name>
</author>
<author><name sortKey="Wszolek, Zk" uniqKey="Wszolek Z">ZK Wszolek</name>
</author>
<author><name sortKey="Ross, Oa" uniqKey="Ross O">OA Ross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Purcell, S" uniqKey="Purcell S">S Purcell</name>
</author>
<author><name sortKey="Neale, B" uniqKey="Neale B">B Neale</name>
</author>
<author><name sortKey="Todd Brown, K" uniqKey="Todd Brown K">K Todd-Brown</name>
</author>
<author><name sortKey="Thomas, L" uniqKey="Thomas L">L Thomas</name>
</author>
<author><name sortKey="Ferreira, Ma" uniqKey="Ferreira M">MA Ferreira</name>
</author>
<author><name sortKey="Bender, D" uniqKey="Bender D">D Bender</name>
</author>
<author><name sortKey="Maller, J" uniqKey="Maller J">J Maller</name>
</author>
<author><name sortKey="Sklar, P" uniqKey="Sklar P">P Sklar</name>
</author>
<author><name sortKey="De Bakker, Pi" uniqKey="De Bakker P">PI de Bakker</name>
</author>
<author><name sortKey="Daly, Mj" uniqKey="Daly M">MJ Daly</name>
</author>
<author><name sortKey="Sham, Pc" uniqKey="Sham P">PC Sham</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Irlande (pays)</li>
<li>Pologne</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Rayaprolu, Sruti" sort="Rayaprolu, Sruti" uniqKey="Rayaprolu S" first="Sruti" last="Rayaprolu">Sruti Rayaprolu</name>
</noRegion>
<name sortKey="Baker, Matt" sort="Baker, Matt" uniqKey="Baker M" first="Matt" last="Baker">Matt Baker</name>
<name sortKey="Bigio, Eileen H" sort="Bigio, Eileen H" uniqKey="Bigio E" first="Eileen H" last="Bigio">Eileen H. Bigio</name>
<name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley F" last="Boeve">Bradley F. Boeve</name>
<name sortKey="Boylan, Kevin B" sort="Boylan, Kevin B" uniqKey="Boylan K" first="Kevin B" last="Boylan">Kevin B. Boylan</name>
<name sortKey="Caselli, Richard" sort="Caselli, Richard" uniqKey="Caselli R" first="Richard" last="Caselli">Richard Caselli</name>
<name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name>
<name sortKey="Ertekin Taner, Nilufer" sort="Ertekin Taner, Nilufer" uniqKey="Ertekin Taner N" first="Nilüfer" last="Ertekin-Taner">Nilüfer Ertekin-Taner</name>
<name sortKey="Ertekin Taner, Nilufer" sort="Ertekin Taner, Nilufer" uniqKey="Ertekin Taner N" first="Nilüfer" last="Ertekin-Taner">Nilüfer Ertekin-Taner</name>
<name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R" last="Graff-Radford">Neill R. Graff-Radford</name>
<name sortKey="Hatanpaa, Kimmo J" sort="Hatanpaa, Kimmo J" uniqKey="Hatanpaa K" first="Kimmo J" last="Hatanpaa">Kimmo J. Hatanpaa</name>
<name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name>
<name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S" last="Knopman">David S. Knopman</name>
<name sortKey="Lippa, Carol" sort="Lippa, Carol" uniqKey="Lippa C" first="Carol" last="Lippa">Carol Lippa</name>
<name sortKey="Lomen Hoerth, Catherine" sort="Lomen Hoerth, Catherine" uniqKey="Lomen Hoerth C" first="Catherine" last="Lomen-Hoerth">Catherine Lomen-Hoerth</name>
<name sortKey="Meschia, James F" sort="Meschia, James F" uniqKey="Meschia J" first="James F" last="Meschia">James F. Meschia</name>
<name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L" last="Miller">Bruce L. Miller</name>
<name sortKey="Mullen, Bianca" sort="Mullen, Bianca" uniqKey="Mullen B" first="Bianca" last="Mullen">Bianca Mullen</name>
<name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C" last="Petersen">Ronald C. Petersen</name>
<name sortKey="Rademakers, Rosa" sort="Rademakers, Rosa" uniqKey="Rademakers R" first="Rosa" last="Rademakers">Rosa Rademakers</name>
<name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A" last="Ross">Owen A. Ross</name>
<name sortKey="Seeley, William W" sort="Seeley, William W" uniqKey="Seeley W" first="William W" last="Seeley">William W. Seeley</name>
<name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J" last="Uitti">Ryan J. Uitti</name>
<name sortKey="White, Charles L" sort="White, Charles L" uniqKey="White C" first="Charles L" last="White">Charles L. White</name>
<name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K" last="Wszolek">Zbigniew K. Wszolek</name>
<name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G" last="Younkin">Steven G. Younkin</name>
</country>
<country name="Irlande (pays)"><noRegion><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name>
</noRegion>
</country>
<country name="Canada"><noRegion><name sortKey="Finger, Elizabeth" sort="Finger, Elizabeth" uniqKey="Finger E" first="Elizabeth" last="Finger">Elizabeth Finger</name>
</noRegion>
<name sortKey="Kertesz, Andrew" sort="Kertesz, Andrew" uniqKey="Kertesz A" first="Andrew" last="Kertesz">Andrew Kertesz</name>
<name sortKey="Mackenzie, Ian R" sort="Mackenzie, Ian R" uniqKey="Mackenzie I" first="Ian R" last="Mackenzie">Ian R. Mackenzie</name>
</country>
<country name="Pologne"><noRegion><name sortKey="Boczarska Jedynak, Magdalena" sort="Boczarska Jedynak, Magdalena" uniqKey="Boczarska Jedynak M" first="Magdalena" last="Boczarska-Jedynak">Magdalena Boczarska-Jedynak</name>
</noRegion>
<name sortKey="Barcikowska, Maria" sort="Barcikowska, Maria" uniqKey="Barcikowska M" first="Maria" last="Barcikowska">Maria Barcikowska</name>
<name sortKey="Krygowska Wajs, Anna" sort="Krygowska Wajs, Anna" uniqKey="Krygowska Wajs A" first="Anna" last="Krygowska-Wajs">Anna Krygowska-Wajs</name>
<name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C62 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C62 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3691612
   |texte=   TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:23800361" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.